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Previous Volume 329:801-802 September 9, 1993 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The rational development of therapy for a disease depends critically on knowledge about its pathogenesis. In the absence of such insight, physicians are vulnerable to the prevailing winds of opinion and practice, each liable to shift from one moment to another. Even when a therapeutic approach seems logical, it must still be proved effective -- not by anecdotal reports, surrogate responses, or public opinion, but by the scientific method and the performance of clinical trials. Such is the case for dietary therapy of adrenoleukodystrophy, a rare and devastating neurodegenerative disease. A recent popular film, Lorenzo's Oil, prematurely implied that dietary . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Kim, J. H., Kim, H. J. (2005). Childhood X-linked Adrenoleukodystrophy: Clinical-Pathologic Overview and MR Imaging Manifestations at Initial Evaluation and Follow-up. RadioGraphics 25: 619-631 [Abstract] [Full Text]  
• Farre, M., Bosch, F., Roset, P. N., Banos, J.-E. (2004). Putting Clinical Pharmacology in Context: The Use of Popular Movies. J Clin Pharmacol 44: 30-36 [Abstract] [Full Text]  
• Eichler, F. S., Itoh, R., Barker, P. B., Mori, S., Garrett, E. S., van Zijl, P. C. M., Moser, H. W., Raymond, G. V., Melhem, E. R. (2002). Proton MR Spectroscopic and Diffusion Tensor Brain MR Imaging in X-linked Adrenoleukodystrophy: Initial Experience. Radiology 225: 245-252 [Abstract] [Full Text]  
• Eichler, F. S., Barker, P. B., Cox, C., Edwin, D., Ulug, A. M., Moser, H. W., Raymond, G. V. (2002). Proton MR spectroscopic imaging predicts lesion progression on MRI in X-linked adrenoleukodystrophy. Neurology 58: 901-907 [Abstract] [Full Text]  
• Hudson Jones, A. (2000). Medicine and the Movies: Lorenzo's Oil at Century's End. ANN INTERN MED 133: 567-571 [Full Text]  
• Rosebush, P. I., Garside, S., Levinson, A. J., Mazurek, M. F. (1999). The Neuropsychiatry of Adult-Onset Adrenoleukodystrophy. J. Neuropsychiatry Clin. Neurosi. 11: 315-327 [Abstract] [Full Text]  
• Restuccia, D., Lazzaro, V. D., Valeriani, M., Oliviero, A., Pera, D. L., Barba, C., Cappa, M., Bertini, E., Capua, M. D., Tonali, P. (1999). Neurophysiologic follow-up of long-term dietary treatment in adult-onset adrenoleukodystrophy. Neurology 52: 810-810 [Abstract] [Full Text]  
• Odone, A., Odone, M., Aubourg, P., Rizzo, W. B. (1994). More on Lorenzo's Oil. NEJM 330: 1904-1905 [Full Text]  
• Unkrig, C. J., Schroder, R., Scharf, R. E., Aubourg, P. (1994). Lorenzo's Oil and Lymphocytopenia. NEJM 330: 577-577 [Full Text]