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Previous Volume 329:811-812 September 9, 1993 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their report in the April 22 issue, Small et al.¹ showed that exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis can occur either during therapy for the original infection or after therapy has been completed. They described three patients seropositive for human immunodeficiency virus (HIV) (Patients 8, 11, and 12) with drug-susceptible tuberculosis whose original tuberculosis strains became resistant to rifampin alone during therapy. This is an unusual observation. The first phenotypic change noted in virtually all persons infected with strains of tuberculosis that become drug resistant is resistance to isoniazid.

We have noted the acquisition of drug . . . [Full Text of this Article]

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