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Editorial
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Volume 329:876-877 September 16, 1993 Number 12
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Reversal of Unawareness of Hypoglycemia

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Brain function depends on an adequate supply of glucose from the blood, and the principal danger of an inadequate supply is the loss of cognitive function. Hypoglycemia sufficient to cause cognitive dysfunction does not normally occur, because small decreases in blood glucose concentrations elicit efficient protective neurohumoral responses, which include activation of the sympathetic nervous system, diminution of endogenous insulin secretion, and release of hyperglycemic hormones such as glucagon, catecholamines, and cortisol. These responses not only act to raise the blood glucose concentration but are also associated with symptoms such as sweating, hunger, and shakiness. Symptoms of neuroglycopenia such as . . . [Full Text of this Article]

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