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Previous Volume 329:957-958 September 23, 1993 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Once again the most appropriate method of administering vitamin K to newborns is under discussion. This fat-soluble naphthoquinone is essential for the gamma-carboxylation of the prothrombin-complex proteins into their active forms, which bind calcium in the coagulation process, as well as proteins C and S. Low plasma levels of these compounds are associated with potentially lethal hemorrhagic disease of the newborn at two to five days of age, when the levels fall to their lowest point¹. Vitamin K given orally or intramuscularly at birth prevents this decrease. Hepatic dysfunction, caused by the immaturity of the liver or by disease . . . [Full Text of this Article]

References

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Extract | Full Text  
N Engl J Med 1994; 330:70-71, Jan 6, 1994. Correspondence

This article has been cited by other articles:

• Davis, D. R. (1994). Vitamin K And The Newborn: A Correction. NEJM 330: 70-70 [Full Text]