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Correspondence
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Volume 329:1046 September 30, 1993 Number 14
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Combination Chemotherapy for ITP

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 by Figueroa, M.
To the Editor: Dr. Figueroa et al. (April 29 issue)1 demonstrated that combination chemotherapy is beneficial to some patients in whom immune thrombocytopenic purpura is refractory to corticosteroids and splenectomy. Since all 10 patients had had splenectomies, were studies performed to exclude the possibility of accessory spleens before combination chemotherapy was given? Accessory spleens are common among middle-aged and older adults and are found in about 20 percent of autopsy cases2,3. They have been associated with recurrent immune thrombocytopenic purpura3,4. Among patients from whom accessory spleens have been removed, remission rates have ranged from 27 to 80 percent3,4. . . [Full Text of this Article]

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