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Previous Volume 329:1049 September 30, 1993 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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By Robert M. Sapolsky. 429 pp., illustrated. Cambridge, Mass., MIT Press, 1992. $55. ISBN 0-262-19320-5.

In this book Dr. Sapolsky, an associate professor of biology at Stanford University and of neuroscience at Stanford University School of Medicine, details his thesis, based on work in rats, that glucocorticoids such as hydrocortisone (cortisol) and dexamethasone damage hippocampal neurons by increasing their sensitivity to ischemic insult or to excitatory neurotoxins, such as kainic acid, that act by stimulating excessive calcium uptake by the neurons. Since the hippocampus normally serves as a target for glucocorticoids and determines the "set-point" of feedback control of the hypothalamic-pituitary-adrenal axis, the deleterious effects of glucocorticoids on the hippocampus could account for accelerating damage . . . [Full Text of this Article]

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