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Previous Volume 329:1124-1128 October 7, 1993 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Hunninghake, D. B. Related Article by Criqui, M. H. PubMed Citation

To the Editor: The study by Hunninghake et al. (April 29 issue),¹ "The Efficacy of Intensive Dietary Therapy Alone or Combined with Lovastatin in Outpatients with Hypercholesterolemia," is very misleading. Despite the title of the article, a National Cholesterol Education Program Step 2 diet represents moderate dietary therapy, not "intensive" therapy. When dietary saturated fat and cholesterol are further restricted, patients tend to have much greater reductions in plasma low-density lipoprotein (LDL) cholesterol levels.

The level of plasma LDL is regulated by the LDL receptor, a cell-surface glycoprotein that removes LDL from plasma by receptor-mediated endocytosis². Most patients with . . . [Full Text of this Article]

References

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• Garrow, J, Watt, G, Doogan, D P, House, A, Freemantle, N, Millard, P H (1994). Conflict of interest: Sometimes consultancies cannot be disclosed. BMJ 308: 471a-471 [Full Text]