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Previous Volume 329:1128-1129 October 7, 1993 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We enjoyed reading Dr. Duffy's comments (May 6 issue),¹ particularly with regard to the mechanisms of chest pain in a patient with systemic mastocytosis. We disagree with the statement that the exacerbation of chest pain after the administration of drugs that typically ameliorate angina argues against coronary disease. Variant angina can be aggravated by beta-blocker therapy². This deleterious effect of beta-blockers could be ascribed to the fact that in human coronary arteries, beta-adrenergic blockade potentiates the vasoconstrictor effect of catecholamines³. Moreover, positive exercise tests have been reported in patients with variant angina⁴. Since there . . . [Full Text of this Article]

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