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Review Article
Mechanisms of Disease
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Volume 329:1246-1253 October 21, 1993 Number 17
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Neuroendocrine-Immune Interactions
Seymour Reichlin

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The long-held view that homeostatic mechanisms are integrated by the nervous and endocrine systems has recently been expanded by information that these systems interact with the immune system. Immune responses alter neural and endocrine function, and in turn, neural and endocrine activity modifies immunologic function1. Many regulatory peptides and their receptors previously thought to be limited to the brain or the immune system are now known to be expressed by both. Findings that link immune and neuroendocrine function provide explanations for the response of the pituitary and adrenal glands to infection and inflammation and the alterations in pituitary-thyroid and . . . [Full Text of this Article]

Neuroimmunology

Neuroimmunomodulation

Neuroregulators and Receptors Common to Immunocompetent and Neuroendocrine Cells

Clinical Importance of the Effects of Inflammation on Neuroendocrine Function

Inflammation-Induced Activation of the Pituitary and Adrenal Glands

Thyroid Abnormalities in Nonthyroidal Illness

Inflammation-Induced Hypogonadism

Psychoneuroimmunology

Conclusions


Source Information

From the Endocrine Division, Department of Medicine, New England Medical Center, Tufts University School of Medicine, 750 Washington St., Boston, MA 02111, where reprint requests should be addressed to Dr. Reichlin.

References




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