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We are told in Leviticus that the blood is the life of the flesh. This perception appears to be shared by several viruses that target blood-forming cells that permit their replication. Studies of virus-blood-cell interaction not only improve our understanding of the pathology related to a particular viral infection but also provide insights into the general physiology of hematopoiesis and the potential of viral vectors for gene therapy. This monograph is particularly timely given the emergence of several therapeutic interventions focused on the bone marrow, including the use of hematopoietic growth factors, mobilization of marrow stem cells for bone marrow
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