The crucial differences between normal cells and cancer cellsstem from discrete changes in specific genes controlling proliferationand tissue homeostasis. Over 100 such cancer-related genes havebeen discovered, several of which are implicated in the naturalhistory of human cancer because they are consistently foundto be mutated in tumors. The p53 tumor-suppressor gene is themost striking example because it is mutated in about half ofalmost all types of cancer arising from a wide spectrum of tissues.Other tumor-suppressor genes important in human cancers, suchas adenomatous polyposis coli, Wilms' tumor type 1, and neurofibromatosistype 1, . . . [Full Text of this Article]
Molecular Mechanisms of p53 Function
Regulation of Transcription of Multiple Genes by the p53 Protein
Clues to the Mechanisms of Cancer Formation from p53 Mutation Patterns in Tumors
Molecular Archaeology: Analysis of Damage to the p53 Gene in Tumors as a Way of Investigating Causes of Cancer
p53 Mutation Profiles in Human Tumors
Hepatocellular Carcinoma
Squamous-Cell Carcinoma of the Skin
Approaches to Molecular Diagnosis, Prognosis, and Therapy
Correlation between the Accumulation of p53 Protein in Neoplastic Cells and the Presence of a Missense Mutation in the p53 Gene
Genetic Screening for Germline p53 Mutations
Immunocytochemical Staining with p53 Antibodies: Biomarker for Cancer
New Diagnostic Strategies Based on the Detection of p53 Antibodies in the Serum of Patients with Cancer
Prognostic Importance of p53 Mutations
Therapy Based on the Renewal of p53 Function
Source Information
From the National Cancer Institute, Laboratory of Human Carcinogenesis, Bethesda, Md. (C.C.H.), and the Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer (World Health Organization), Lyons, France (M.H.).
Address reprint requests to Dr. Harris at the National Cancer Institute, Laboratory of Human Carcinogenesis, Bldg. 37, Rm. 2C01, Bethesda, MD 20892.
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