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Previous Volume 329:1343-1344 October 28, 1993 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In children with acute lymphoblastic leukemia (ALL), rates of complete remission ranging from 90 to 95 percent and rates of long-term disease-free survival approaching 70 percent can now be achieved. In this issue of the Journal, Rivera and colleagues¹ show convincing improvement in disease-free survival, from 9 to 71 percent, over a period of nearly 30 years. The development of effective antileukemic combination chemotherapy, the introduction of prophylactic treatment for relapse of leukemia in the meninges, and recent, more aggressive strategies involving the earlier use of intensive therapy (thereby probably avoiding multidrug resistance) are among the reasons for this success. . . . [Full Text of this Article]

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