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Correspondence
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Volume 329:1354-1356 October 28, 1993 Number 18
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Blood Transfusions and Prognosis in Colorectal Cancer

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by Busch, O.
To the Editor: Busch et al. (May 13 issue)1 fail to consider the possibility that both autologous and allogeneic blood may contain an immunosuppressive factor that could influence the rate of recurrence of colorectal cancer. Until recently, it was generally thought that the cellular components of transfused blood were responsible for the immunomodulatory effects of transfusion, particularly in renal transplantation. Evidence is accumulating, however, to implicate other components. In colorectal cancer, transfusions of plasma protein fractions and fresh-frozen plasma have been associated with increased tumor recurrence2,3. Experimental work suggests that humoral rather than cellular components may be more important . . . [Full Text of this Article]

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