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Previous Volume 329:129-130 July 8, 1993 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The clinical use of heparin as an anticoagulant and antithrombotic agent is established practice in prophylaxis against postoperative deep-vein thrombosis, in the initial treatment of overt deep-vein thrombosis, and in the prevention of thrombosis during extracorporeal circulation¹. With its anticoagulant and antithrombotic action, heparin primarily binds to and accelerates the plasma inhibitor antithrombin III, and it has essential interactions with various coagulation proteinases. Furthermore, its interaction with other inhibitory proteins, such as heparin cofactor II and tissue-factor-pathway inhibitor, promotes additional proteinase inhibitory reactions^2,3,4.

Heparin is a highly sulfated, unbranched glycosaminoglycan present in the mast cells of most mammals. . . . [Full Text of this Article]

References

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