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Correspondence
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Volume 329:1583 November 18, 1993 Number 21
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Histamine Release in Chronic Idiopathic Urticaria

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 by Hide, M.
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To the Editor: In their article describing autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria, Hide et al. (June 3 issue)1 state that the majority of patients with severe, chronic urticaria have an immediate wheal-and-flare response after intradermal injection of autologous serum. Have the authors investigated this phenomenon in patients with acute hives? If so, is chronic urticaria more likely to develop in patients with a positive reaction to their own serum? One of my patients with acute hives of unknown cause had a positive result on skin testing with autologous serum. When . . . [Full Text of this Article]

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