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Previous Volume 329:1808-1810 December 9, 1993 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Despite years of research, multiple sclerosis remains one of the most difficult neurologic disorders to understand and treat. Acute optic neuritis is a common manifestation of multiple sclerosis, either a first manifestation or one appearing during the course of the illness. When optic neuritis occurs in a person with no past evidence of multiple sclerosis, other causes of optic-nerve dysfunction must be excluded, such as local compression of the nerve, vascular disease, sarcoidosis, syphilis, or another systemic disorder. If optic neuritis occurs in isolation, it is termed idiopathic and presumed to be due to inflammation and demyelination of the optic . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Volpe, N. J. (2008). The Optic Neuritis Treatment Trial: A Definitive Answer and Profound Impact With Unexpected Results. Arch Ophthalmol 126: 996-999 [Full Text]  
• Kaufman, D. I., Trobe, J. D., Eggenberger, E. R., Whitaker, J. N. (2000). Practice parameter: The role of corticosteroids in the management of acute monosymptomatic optic neuritis: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 54: 2039-2044 [Full Text]  
• McDonald, W I (1999). Physicians, subsequence and consequence. J. Neurol. Neurosurg. Psychiatry 67: 282-289 [Full Text]  
• Smith, P. F, Darlington, C. L (1999). Recent developments in drug therapy for multiple sclerosis. Mult Scler 5: 110-120 [Abstract]  
• Sellebjerg, F., Nielsen, H. S., Frederiksen, J. L., Olesen, J. (1999). A randomized, controlled trial of oral high-dose methylprednisolone in acute optic neuritis. Neurology 52: 1479-1479 [Abstract] [Full Text]  
• Slavin, M. L., Burde, R. M. (1994). Prepublication Blackout in the Optic Neuritis Treatment Trial. Arch Ophthalmol 112: 581-581 [Abstract]