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Correspondence
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Volume 329:1963-1964 December 23, 1993 Number 26
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Brain Tumors in Infants

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 by Allen, J. C.
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 by Duffner, P. K.
To the Editor: The treatment of infants with malignant brain tumors by maximal resection and chemotherapy, with radiation treatment delayed to the age of 24 to 48 months (June 17 issue),1 is an important new strategy with the objective of decreasing morbidity due to radiation. For this objective to be attained, it is necessary to demonstrate that survival is not decreased and that the early and late toxic effects of systemic therapy are less than the incremental toxic effects associated with radiation treatment at an earlier age. Since the study did not have control subjects, the authors sought assurance that . . . [Full Text of this Article]

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