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Previous Volume 329:2038-2039 December 30, 1993 Number 27 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In evaluating the effect of topical tretinoin (retinoic acid) cream on the skin, Griffiths et al. (Aug. 19 issue)¹ conclude that tretinoin causes an 80 percent increase in extracellular type I collagen formation in the papillary dermis. Evaluation in terms of the percentage differences in dermal type I collagen formation was based on a subjective scoring system used to assess the intensity and extent of immunostaining of a portion of the procollagen I molecule. Ordinal values of 0 to 5 were used to describe the perceived intensity and extent of staining in prepared immunohistologic tissue sections.

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