Human herpesvirus 6 (HHV-6) was first isolated from patientswith the acquired immunodeficiency syndrome or lymphoproliferativediseases and was named human B-lymphotropic virus1. However,later studies revealed that the virus is T-lymphotropic in vitro2and in vivo3. Recently, two genotypes of HHV-6 (type A and typeB) have been distinguished on the basis of their restrictionpolymorphism4,5,6. HHV-6 has been identified as the etiologicagent of exanthem subitum in infants,7 and an acute febrileillness in young children8. Most people are seropositive forHHV-6 by the age of three years9,10.
Examination of Herpesvirus DNA by the Polymerase Chain Reaction
Genotyping of HHV-6
Results
Discussion
Source Information
From the Departments of Hematology (K.A.) and Dermatology (S.H.), Harasanshin General Hospital, Fukuoka, Japan; the Department of Microbiology, Miyazaki Medical College, Miyazaki, Japan (Y.E., T.M., Y.M.); the First Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan (Y.S., M.K.); and the First Department of Internal Medicine, Kyushu University, Fukuoka, Japan (M.H., Y.N.).
Address reprint requests to Dr. Akashi at the Department of Hematology, Harasanshin General Hospital, 1-8 Taihaku-machi, Hakata-ku, Fukuoka 812, Japan.
References
Related Letters:
Primary Human Herpesvirus 6 Infection in an Adult
Morris D. J., Appleton A. L., Sviland L., Schmidt C.A., Wilborn F.F., Siegert W., Cone R., Corey L., Hackman R., Akashi K., Eizuru Y., Sumiyoshi Y.
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N Engl J Med 1993;
329:1817-1819, Dec 9, 1993.
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