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Previous Volume 329:433-434 August 5, 1993 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Brain natriuretic peptide was originally isolated from the mammalian brain^1,2 and acts as a cardiac hormone resembling atrial natriuretic peptide^3,4. Brain natriuretic peptide is synthesized primarily by the ventricles, and its expression in the ventricles is induced in ventricular overload and hypertrophy⁵. These observations suggest the possible involvement of this peptide in the pathophysiology of hypertrophic cardiomyopathy.

We measured plasma concentrations of brain natriuretic peptide in 15 asymptomatic patients with nonobstructive hypertrophic cardiomyopathy (mean [±SD] age, 14.4 ±5.1 years), 35 age-matched patients with left ventricular hypertrophy due to pressure overload (i.e., aortic stenosis or coarctation . . . [Full Text of this Article]

References

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• Cambronero, F., Marin, F., Roldan, V., Hernandez-Romero, D., Valdes, M., Lip, G. Y.H. (2009). Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis. Eur Heart J 0: ehn538v1-13 [Abstract] [Full Text]  
• Neverdal, N. O., Knudsen, C. W., Husebye, T., Vengen, O. A., Pepper, J., Lie, M., Tonnessen, T. (2006). The effect of aortic valve replacement on plasma B-type natriuretic peptide in patients with severe aortic stenosis -- one year follow-up. Eur J Heart Fail 8: 257-262 [Abstract] [Full Text]  
• Ebihara, K., Kusakabe, T., Masuzaki, H., Kobayashi, N., Tanaka, T., Chusho, H., Miyanaga, F., Miyazawa, T., Hayashi, T., Hosoda, K., Ogawa, Y., Nakao, K. (2004). Gene and Phenotype Analysis of Congenital Generalized Lipodystrophy in Japanese: A Novel Homozygous Nonsense Mutation in Seipin Gene. J. Clin. Endocrinol. Metab. 89: 2360-2364 [Abstract] [Full Text]  
• Nakamura, T., Sakamoto, K., Yamano, T., Kikkawa, M., Zen, K., Hikosaka, T., Kubota, T., Azuma, A., Nishimura, T. (2002). Increased plasma brain natriuretic peptide level as a guide for silent myocardial ischemia in patients with non-obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 39: 1657-1663 [Abstract] [Full Text]  
• Hirata, Y., Matsumoto, A., Aoyagi, T., Yamaoki, K., Komuro, I., Suzuki, T., Ashida, T., Sugiyama, T., Hada, Y., Kuwajima, I., Nishinaga, M., Akioka, H., Nakajima, O., Nagai, R., Yazaki, Y. (2001). Measurement of plasma brain natriuretic peptide level as a guide for cardiac overload. Cardiovasc Res 51: 585-591 [Abstract] [Full Text]  
• Struthers, A D (1994). Fortnightly Review: Ten years of natriuretic peptide research: a new dawn for their diagnostic and therapeutic use?. BMJ 308: 1615-1619 [Full Text]