Body temperature, like other fundamental aspects of human biology,is closely regulated by intricate control mechanisms. Thesehomeostatic controls allow body temperature to display a predictablediurnal rhythmicity, increasing from a nadir of about 36 °Cin the early morning to approximately 37.5 °C in late afternoon1.A variety of disorders can elevate body temperature; those resultingfrom thermoregulatory failure are properly called hyperthermia,whereas those resulting from intact homeostatic responses arecategorized as fever.
Thermoregulation
Body temperature is a balance between heat production and heatdissipation. Heat is generated internally as a byproduct ofall metabolic processes; when ambient . . . [Full Text of this Article]
Selected Hyperthermic Disorders
Exertional Hyperthermia
Heat Stroke
Malignant Hyperthermia of Anesthesia
Neuroleptic Malignant Syndrome
Hormonal Hyperthermia
Miscellaneous Causes of Hyperthermia
Therapeutic Hyperthermia
The Consequences of Hyperthermia
The Management of Hyperthermia
Source Information
From the Infectious Disease Unit and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.
Address reprint requests to Dr. Simon at the Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital, Fruit St., Boston, MA 02114.
References
Related Letters:
Hyperthermia
Sessler D. I., Parness J., Slovis C. M., Salzberg M. R.
Extract |
Full Text
N Engl J Med 1994;
330:218-219, Jan 20, 1994.
Correspondence
The Neurologic Basis of Fever
MacKenzie M. A., Pieters G. F.F.M., Hermus A. R.M.M., Wheless J. W., El-Radhi A.S., Saper C. B., Breder C. D.
Extract |
Full Text
N Engl J Med 1994;
331:1308-1309, Nov 10, 1994.
Correspondence
This article has been cited by other articles:
Romanovsky, A. A., Almeida, M. C., Garami, A., Steiner, A. A., Norman, M. H., Morrison, S. F., Nakamura, K., Burmeister, J. J., Nucci, T. B.
(2009). The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not. Pharmacol. Rev.
61: 228-261
[Abstract][Full Text]
Siddegowda, Y. K. B., Leo, M. D. M., Kumar, D., Hooda, O. K., Prakash, V. R., Mishra, S. K.
(2007). Vascular: Influence of heat stress on the reactivity of isolated chicken carotid artery to vasoactive agents. Exp Physiol
92: 1077-1086
[Abstract][Full Text]
Wright, C. L., Boulant, J. A.
(2007). Carbon dioxide and pH effects on temperature-sensitive and -insensitive hypothalamic neurons. J. Appl. Physiol.
102: 1357-1366
[Abstract][Full Text]
Varghese, G M, John, G, Thomas, K, Abraham, O C, Mathai, D
(2005). Predictors of multi-organ dysfunction in heatstroke. Emerg. Med. J.
22: 185-187
[Abstract][Full Text]
Stephan, F., Ghiglione, S., Decailliot, F., Yakhou, L., Duvaldestin, P., Legrand, P.
(2005). Effect of excessive environmental heat on core temperature in critically ill patients. An observational study during the 2003 European heat wave. Br J Anaesth
94: 39-45
[Abstract][Full Text]
Scheers-Masters, J. R., Schootman, M., Thach, B. T.
(2004). Heat Stress and Sudden Infant Death Syndrome Incidence: A United States Population Epidemiologic Study. Pediatrics
113: e586-e592
[Abstract][Full Text]
DuBose, D. A., Wenger, C. B., Flinn, S. D., Judy, T. A., Dubovtsev, A. I., Morehouse, D. H.
(2003). Distribution and mitogen response of peripheral blood lymphocytes after exertional heat injury. J. Appl. Physiol.
95: 2381-2389
[Abstract][Full Text]
O'Connor, M. J., Rembold, C. M.
(2002). Heat-induced force suppression and HSP20 phosphorylation in swine carotid media. J. Appl. Physiol.
93: 484-488
[Abstract][Full Text]
Liu, C.-C., Chien, C.-H., Lin, M.-T.
(2000). Glucocorticoids reduce interleukin-1{beta} concentration and result in neuroprotective effects in rat heatstroke. J. Physiol.
527: 333-343
[Abstract][Full Text]
KITAZAWA, K., HONDA, A., MAEMOTO, T., INAKAWA, N., KAWATE, K.
(1999). Botryoid neutrophils in unexpected heat stroke. Arch. Dis. Child.
81: 189l-189
[Full Text]
Mikane, T., Araki, J., Suzuki, S., Mizuno, J., Shimizu, J., Mohri, S., Matsubara, H., Hirakawa, M., Ohe, T., Suga, H.
(1999). O2 cost of contractility but not of mechanical energy increases with temperature in canine left ventricle. Am. J. Physiol. Heart Circ. Physiol.
277: H65-H73
[Abstract][Full Text]
Yang, Y.-L., Lin, M.-T.
(1999). Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke. Am. J. Physiol. Heart Circ. Physiol.
276: H1961-H1967
[Abstract][Full Text]
Gurrera, R. J.
(1999). Sympathoadrenal Hyperactivity and the Etiology of Neuroleptic Malignant Syndrome. Am. J. Psychiatry
156: 169-180
[Abstract][Full Text]
Chaves-Carballo, E., Bouchama, A.
(1998). Fever, Heatstroke, and Hemorrhagic Shock and Encephalopathy. J Child Neurol
13: 286-287
Krach, L. E., Kriel, R. L., Morris, W. F., Warhol, B. L., Luxenberg, M. G.
(1997). Central Autonomic Dysfunction Following Acquired Brain Injury in Children. Neurorehabil Neural Repair
11: 41-45
[Abstract]
Kellermann, A. L., Todd, K. H.
(1996). Killing Heat. NEJM
335: 126-127
[Full Text]
MacKenzie, M. A., Pieters, G. F.F.M., Hermus, A. R.M.M., Wheless, J. W., El-Radhi, A.S., Saper, C. B., Breder, C. D.
(1994). The Neurologic Basis of Fever. NEJM
331: 1308-1309
[Full Text]
Anceno-Reyes, R. I.
(1994). Acute Fevers of Unknown Origin. Arch Intern Med
154: 2253-2254
[Abstract]
DiNubile, M. J.
(1994). Acute Fevers of Unknown Origin-Reply. Arch Intern Med
154: 2254-2254
[Abstract]
Saper, C. B., Breder, C. D.
(1994). The Neurologic Basis of Fever. NEJM
330: 1880-1886
[Full Text]
Sessler, D. I., Parness, J., Slovis, C. M., Salzberg, M. R.
(1994). Hyperthermia. NEJM
330: 218-219
[Full Text]
Previous
