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Previous Volume 329:571-572 August 19, 1993 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The human genome is often viewed as a stable collection of genes, embedded both in the DNA necessary to regulate their expression and in the chromosomal packaging. According to this relatively static picture, genetic diseases may be caused by rare mutation events that damage a gene, deleting a portion or altering its coding sequence. However, the human genome is also populated by DNA sequences that are not at all static, but vary with considerable frequency. This issue of the Journal presents an example of one such sequence, particular variants of which are associated with an increased risk of cancer¹. . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Martin, J. (1993). Molecular genetics of neurological diseases. Science 262: 674-676