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Correspondence
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Volume 329:580 August 19, 1993 Number 8
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HTLV tax and Mycosis Fungoides

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To the Editor: Although a causal relation between human T-cell lymphotropic retrovirus type I and type II (HTLV-I and HTLV-II) and adult T-cell leukemia has been well established, the association between HTLVs and the cutaneous T-cell neoplasm mycosis fungoides has remained controversial. Few patients with mycosis fungoides are seropositive for antibodies to structural components of HTLV I and II virions; a typical figure is about 15 percent. When HTLV-I- or HTLV-II-related proviral DNA sequences have been detected, they have often been found to be incomplete1,2,3. Nonetheless, cultures of peripheral-blood mononuclear cells from the majority of patients with mycosis fungoides . . . [Full Text of this Article]

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