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Previous Volume 329:586-587 August 19, 1993 Number 8 Next

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By Victor A. Bernstam. 695 pp. Boca Raton, Fla., CRC Press, 1992. $99.50. ISBN 0-8493-6824-3.

This remarkable book can be seen as heralding the coming of age of the "first wave" of the new era of molecular medicine -- DNA-based diagnostics (the imminent second wave being gene therapy). Forty years after the elucidation of the double helical structure of DNA by Watson and Crick, their aesthetically beautiful molecule is now finding a place as an accepted analyte (and reagent) in clinical laboratories. This new-found power to uncover diagnoses at the molecular level, even before the appearance of symptoms or before birth, promises to revolutionize the practice of medicine. Yet at present the discipline is considered . . . [Full Text of this Article]

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