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Previous Volume 329:587-588 August 19, 1993 Number 8 Next

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Edited by Roger N. Rosenberg, Stanley B. Prusiner, Salvatore Dimauro, Robert L. Barchi, and Louis M. Kunkel. 1023 pp., illustrated. Boston, Butterworth-Heinemann, 1993. $225. ISBN 0-7506-9069-0.
(Molecular Basis of Clinical Medicine.) Edited by P. Michael Conneally. 296 pp., illustrated. Boston, Blackwell Scientific, 1993. $39.95. ISBN 0-86542-150-1.

Over the past decade, molecular genetic investigations of neurologic disease have entered a veritable golden age. With the recent cloning of the genes for Huntington's disease, amyotrophic lateral sclerosis, and neurofibromatosis 1 and 2, among others, molecular-based studies of nervous-system disorders reached a new pinnacle. They not only serve as effective models for logically determining the etiologic basis of inherited maladies in humans, but also are beginning to confirm the momentous promise of molecular biology for eventually treating neurogenetic abnormalities. It is not surprising, then, that this field has progressed at a whirlwind pace. Even those who are deeply immersed . . . [Full Text of this Article]

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