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Previous Volume 330:38-47 January 6, 1994 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The dramatic hemorrhages, the effect of the disease on history through its presence in Queen Victoria's descendants, and the devastating role of therapeutic concentrates in the transmission of the acquired immunodeficiency syndrome (AIDS) have made hemophilia A the object of great medical, scientific, and public interest. The commonest hereditary coagulation disorder and a disease without ethnic or geographic limitations, its incidence approaches 20 per 100,000 male births^1,2,3. John Conrad Otto emphasized its inheritance as an X-linked disorder in his 1803 description of the disease in a New Hampshire family: "males only are subject to this strong affection . . . . . [Full Text of this Article]

The Role of Factor VIII in Blood Coagulation

The Structure and Function of Factor VIII

Molecular Genetics of Hemophilia A

Clinical Presentation

Factor VIII Replacement Therapy

Clinical Management

Genetic Counseling and Prenatal Diagnosis

The Future

Source Information

From the Holland Laboratory, American Red Cross Biomedical Services, 15601 Crabbs Branch Way, Rockville, MD 20855, where reprint requests should be addressed to Dr. Hoyer.

References

Related Letters:

Hemophilia A
Pierce G. F., Rosner F.
Extract | Full Text  
N Engl J Med 1994; 330:1617, Jun 2, 1994. Correspondence

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