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Previous Volume 330:61-62 January 6, 1994 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Dantal et al. report the remarkable observation that the removal of serum proteins by adsorption to protein A Sepharose led to remission of proteinuria in patients with recurrences of the nephrotic syndrome after transplantation¹. The conclusion that the remissions were due to the removal of a culprit substance is strengthened by the finding that eluates from the protein A Sepharose caused proteinuria in rats. Protein A Sepharose was presumably chosen to adsorb immunoglobulins; the serendipitous finding of the role of a substance thought not to be an immunoglobulin demonstrates that the intelligent pursuit . . . [Full Text of this Article]

References

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• DeBrito, T., Nussenzveig, I., Carneiro, C. R. W., Nakhle, M. C., Carvalho, S., Silva, A. M. G., Sandoval, M., Saldanha, L. B. (1999). Glomerular Detection of Schistosomal Antigen by Immunoelectron Microscopy in Human Mansonian Schistosomiasis. INT J SURG PATHOL 7: 217-225 [Abstract]