FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 330:709-711 March 10, 1994 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

In a normal adult, 2 x 10¹¹ worn-out red cells die every day. In replacing them with an equal number of fresh erythrocytes, the bone marrow synthesizes 4 x 10¹⁴ molecules of hemoglobin per second. These hemoglobin molecules consist of two equal partners: heme and globin. To make heme, an atom of iron is inserted from the young erythroblast into the center of an intensely colored ring of protoporphyrin IX; simultaneously, the developing red cell synthesizes two kinds of globin chains, and , which are joined to the heme molecule. The developing red cells coordinate these components of hemoglobin synthesis . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Youssef, S., Hachem, R., Chemaly, R. F., Adachi, J., Ying, J., Rolston, K., Raad, I. (2008). The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer. J Antimicrob Chemother 61: 421-424 [Abstract] [Full Text]  
• Spellberg, B., Yoo, T., Bayer, A. S. (2004). Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6. J Antimicrob Chemother 54: 832-835 [Abstract] [Full Text]