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Volume 330:716-717 March 10, 1994 Number 10
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Neurologic Complications of Heart Surgery in Infants

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 by Newburger, J. W.
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To the Editor: Newburger et al. (Oct. 7 issue)1 report a higher incidence of clinical and electroencephalographic seizure activity in infants subjected to profound hypothermia and circulatory arrest than in those subjected to profound hypothermia and low-flow cardiopulmonary bypass. Although blood viscosity would have been increased in both groups with profound hypothermia, the likelihood of microvascular sludging with resultant cerebral ischemia and infarction may have been greater in the group subjected to total circulatory arrest. Hemodilution improves the rheologic characteristics of blood at low temperatures2 and is safe because of the decreased demand for oxygen and, hence, hemoglobin for the . . . [Full Text of this Article]

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