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Previous Volume 330:786-787 March 17, 1994 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The retinoblastoma gene (RB) was identified because of germ-line mutations that strongly predisposed infants with the mutant gene to a rare cancer of the retina. However, the RB protein turned out to be a regulator of transcription in all cells of adults. The active form of the protein represses the expression of genes required for cells to proceed through the cycle of cell division. Phosphorylation, mediated by a complex of several proteins regulated by the cell cycle (a cyclin and a cyclin-dependent kinase), inactivates the RB protein, allowing cell division to begin.

It is easy to understand that mutations resulting . . . [Full Text of this Article]

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