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Previous Volume 330:839-846 March 24, 1994 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hematopoietic growth factors promote both growth and differentiation of blood cells^1,2. These factors activate specific hematopoietic growth factor receptors that are expressed on the surface of blood progenitor cells of the bone marrow. The past decade has witnessed the identification and cloning of several genes for hematopoietic growth factors and growth factor receptors. The availability of the complementary DNA encoding these polypeptides has provided tools for understanding the normal process of blood-cell production and the abnormal processes of leukemia and other diseases in humans.

Hematopoietic Growth Factors

The identification of hematopoietic growth factors was made possible primarily by the cell-culture assays for . . . [Full Text of this Article]

Hematopoietic Growth Factor Receptors

Cytokine Receptors in Congenital Disease

Familial Erythrocytosis

X-Linked Severe Combined Immunodeficiency

Kostmann's Syndrome

Laron Dwarfism

Other Congenital Diseases

Implications for Diagnosis and Therapeutic Intervention

Implications for the Study of Biologic Aspects of Receptors

Conclusions

Discussion

Source Information

From the Division of Pediatric Oncology and the Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston.

Address reprint requests to Dr. D'Andrea at the Division of Pediatric Oncology and the Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115.

References

This article has been cited by other articles:

• Subtil, A, Hemar, A, Dautry-Varsat, A (1994). Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited. J. Cell Sci. 107: 3461-3468 [Abstract]