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Editorial
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Volume 330:857-858 March 24, 1994 Number 12
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HLA Matching and Cardiac Transplantation

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The time constraints of cardiac transplantation -- namely, the need to implant the donor organ within four hours of its removal -- have prevented cardiac surgeons from considering prospective HLA matching of the donor and recipient, even if they thought it worthwhile. Several retrospective, single-center reports over the past six years suggest that there are fewer episodes of rejection and better graft survival among recipients of a well-matched heart1,2,3,4,5,6,7,8,9,10. In general, compatibility for the HLA-DR locus had the greatest influence on graft outcome, as first noted many years previously for kidney transplantation11 and confirmed in large cohorts of patients . . . [Full Text of this Article]

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