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Correction to Schwartz, N Engl J Med 330(4):283-284 January 27, 1994.

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Volume 330:942-943 March 31, 1994 Number 13
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The GPI Tail: Correction

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 by Schwartz, R. S.
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 by Schwartz, R. S.
To the Editor: I would like to point out a mistake in the figure accompanying Dr. Schwartz's editorial (Jan. 27 issue)1. As shown in the figure, the glycosyl-phosphatidylinositol (GPI) tail extends through the entire membrane bilayer. This is incorrect. The GPI anchor is composed of a conserved glycan core attached to an inositol phospholipid that transverses only the outer leaflet of the membrane bilayer2,3,4. The correct PIG tail, as the GPI anchor is fondly called by enthusiasts, is shown in Figure 1.


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Figure 1. Corrected Diagram Showing the Structure of the GPI Anchor (Shaded Area) and Its Position in . . . [Full Text of this Article]

 
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