To the Editor: In the November 18 issue of the Journal, Dannet al.1 reported a case of tumor lysis syndrome after treatmentwith 2-chlorodeoxyadenosine (cladribine) in a patient with refractorychronic lymphocytic leukemia. We would like to report anothercase of tumor lysis syndrome resulting from treatment with 2-chlorodeoxyadenosine.
A 59-year-old man presented to the Mayo Clinic for a secondopinion concerning therapy for his chronic myelogenous leukemiain chronic phase, which had been diagnosed approximately 18months earlier. The patient could not tolerate hydroxyurea,had dose-limiting thrombocytopenia when treated with busulfan,and did not want to try interferon . . . [Full Text of this Article]
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