Carcinoma of the large bowel, which will afflict over 150,000Americans this year, is second only to lung cancer as a causeof death from cancer1. Although most patients present with surgicallyresectable disease, almost half die of the cancer. Radiationtherapy has a largely palliative role. In the past, chemotherapyresulted in only infrequent and usually transient shrinkageof the tumor, scarcely justifying the discomforts and costsof the treatment. In recent years, however, there have beensome advances. In the discussion that follows, credence is givenonly to therapeutic claims validated by controlled trials withsufficiently long . . . [Full Text of this Article]
Therapy for Advanced and Metastatic Colorectal Cancer
Systemic Therapy with Fluorinated Pyrimidines
Hepatic Arterial Infusion of Floxuridine
Biochemical Modulation: A New Approach to Fluorouracil Therapy
Adjuvant Therapy for Colorectal Cancer
Postoperative Adjuvant Therapy for Colon Cancer
Adjuvant Therapy for Rectal Cancer
Future Directions in Adjuvant Therapy for Colorectal Cancer
Conclusions
Source Information
From the Mayo Clinic, Rochester, MN 55905, where reprint requests should be addressed to Dr. Moertel.
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