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Previous Volume 330:1159 April 21, 1994 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: On reading the article by Vowels et al. (Nov. 25 issue)¹ on the use of cord-blood stem cells to correct X-linked lymphoproliferative disease, we were troubled by the authors' cavalier attitude concerning clamping of the umbilical cord of the newborn donor. They state that early clamping is safe but offer no data to substantiate this claim. There is evidence in the literature that early clamping of the umbilical cord increases the incidence of intraventricular hemorrhage in the neonate^2,3.

Mark Ende, M.D.
Frederick I. Ende, M.D.
121 S. Market St.
Petersburg, VA 23803

References

1. Vowels MR, Lam-Po-Tang R, Berdoukas V, et al. Correction of X-linked lymphoproliferative disease by transplantation of cord-blood stem cells. N Engl J Med 1993;329:1623-1625. [Free Full Text]
2. Hofmeyr GJ, Bex PJM, Skapinker R, Delahunt T. Hasty clamping of the umbilical cord may initiate neonatal intraventricular hemorrhage. Med Hypotheses 1989;29:5-6. [Medline]
3. Hofmeyr GJ, Bolton KD, Bowen DC, Govan JJ. Periventricular/intraventricular haemorrhage and umbilical cord clamping: findings and hypothesis. S Afr Med J 1988;73:104-106. [Medline]

To . . . [Full Text of this Article]

References

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