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Previous Volume 330:1164 April 21, 1994 Number 16 Next

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Edited by Bruce D. Cheson. 424 pp., illustrated. New York, Marcel Dekker, 1993. $99.75. ISBN 0-8247-8736-6.

Chronic lymphocytic leukemia is the most common hematologic cancer in the United States. There has been a need for a comprehensive review of the disease, especially in the light of recent advances in the understanding of its pathophysiology and treatment. This important book fills this need.

The book is divided into 18 chapters, all by different authors. The first 11 chapters discuss the immunology and molecular biology of chronic lymphocytic leukemia and the physiologic bases of treatment and drug resistance. A chapter on purine analogues is a thorough review of the mechanisms of this important class of antimetabolites. A superb, . . . [Full Text of this Article]

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