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Previous Volume 330:1241 April 28, 1994 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: An outbreak of tuberculosis resistant to rifampin, isoniazid, streptomycin, and ethambutol occurred in our institution¹ in association with conversions among our health care workers after tuberculin skin testing. Sixteen workers entered a six-month investigational trial of ofloxacin (800 mg a day) and pyrazinamide (1500 mg a day), after approval by the appropriate review boards.

Adverse effects due to these drugs were very common. Of the 16 workers, 14 discontinued prophylaxis after less than six months; 13 workers had one or more adverse effects, including arthralgia (7 workers), gastrointestinal distress (6), hepatitis with alanine aminotransferase levels of 491 . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Chan, E. D, Iseman, M. D (2002). Current medical treatment for tuberculosis. BMJ 325: 1282-1286 [Full Text]  
• Papastavros, T., Dolovich, L. R., Holbrook, A., Whitehead, L., Loeb, M. (2002). Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis. CMAJ 167: 131-136 [Abstract] [Full Text]