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Volume 330:1276-1278 May 5, 1994 Number 18
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Molecular Biology and the Early Detection of Carcinoma of the Bladder -- The Case of Hubert H. Humphrey
Ralph H. Hruban, Peter van der Riet, Yener S. Erozan, and David Sidransky

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Approximately 52,300 new cases of carcinoma of the bladder were diagnosed in the United States in 19931. These carcinomas struck primarily older men, who often presented with hematuria or increased frequency of urination. Patients whose cancers are detected in an early, localized stage have a 90 percent chance of surviving at least five years. If the cancer is detected after distant spread of the disease, however, the five-year survival rate drops to 9 percent1. Clearly, techniques for the early detection of carcinoma of the bladder can have a major impact on the outcome of the disease2.

Cytologic . . . [Full Text of this Article]

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From the Departments of Pathology (R.H.H., Y.S.E.) and Otolaryngology-Head and Neck Surgery (R.H.H., P.R., D.S.), Johns Hopkins Medical Institutions, Baltimore. Presented in part at the annual meeting of the U.S. and Canadian Academy of Pathology, San Francisco, March 16, 1994.

Address reprint requests to Dr. Sidransky at the Department of Otolaryngology-Head and Neck Surgery, 818 Ross Research Bldg., 720 Rutland Ave., Baltimore, MD 21205-2195.

References


Related Letters:

Hubert Humphrey's Bladder Cancer
Homer R. J., Braund W.J., Hruban R. H., van der Riet P., Sidransky D.
Extract | Full Text  
N Engl J Med 1994; 331:880-881, Sep 29, 1994. Correspondence

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