FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 330:1386-1387 May 12, 1994 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Primary biliary cirrhosis, a progressive cholestatic liver disease that primarily affects middle-aged women, has been called a "model autoimmune disease"¹. The numerous abnormalities of the humoral and cellular immune systems include elevated serum levels of immunoglobulins, multiple circulating autoantibodies, granulomas in the liver and regional lymph nodes, and impaired regulation of both B and T lymphocytes^1,2. The chronic cholestasis is due to relentless destruction of small and medium-sized bile ducts mediated by activated T lymphocytes, both CD4 and CD8 cells². In contrast to hepatocytes, bile ducts lack the ability to regenerate when they are destroyed, or do . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Miyoshi, H., Rust, C., Guicciardi, M. E., Gores, G. J. (2001). NF-{{kappa}}B Is Activated in Cholestasis and Functions to Reduce Liver Injury. Am. J. Pathol. 158: 967-975 [Abstract] [Full Text]  
• Sodeman, T., Bronk, S. F., Roberts, P. J., Miyoshi, H., Gores, G. J. (2000). Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G992-G999 [Abstract] [Full Text]  
• Kaplan, M. M. (1996). Primary Biliary Cirrhosis. NEJM 335: 1570-1580 [Full Text]  
• (1994). URSODIOL FOR PRIMARY BILIARY CIRRHOSIS. JWatch General 1994: 1-1 [Full Text]