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Book Review
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Volume 330:1397-1398 May 12, 1994 Number 19

The Molecular Pathology of Autoimmune Diseases
Autoimmunity: Physiology and Disease

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Edited by Constantin A. Bona, Katherine A. Siminovitch, Maurizio Zanetti, and Argyrios N. Theofilopoulos. 795 pp., illustrated. Langhorne, Pa., Harwood Academic, 1993. $175. ISBN 3-7186-0555-4.
Edited by Antonio Coutinho and Michel D. Kazatchkine. 459 pp. New York, Wiley-Liss, 1994. $84.95. ISBN 0-471-59227-7.

The skepticism that once prevailed when the topic of autoimmunity came up in a discussion, or when a "so-called" autoimmune disease entered the differential diagnosis, is difficult to appreciate today. The dogma of the time -- an era that began around 1930 and ended, finally, around 1960 -- was that an antibody could not be an autoantibody. This assumption swayed otherwise reasonable people to invent labels like "erythrocyte-coating substances," even though they knew that those "substances" were antibodies.

"So-called" began disappearing from the beginning of "autoimmune disease" about 35 years ago; one interesting reason for the new attitude was the . . . [Full Text of this Article]




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