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Previous Volume 330:143 January 13, 1994 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hepatitis C virus (HCV) is a major cause of chronic liver disease and of hepatocellular carcinoma. Several strains of HCV exist; distinct genotypes can be identified by sequence comparison of the viral genomes.¹ Recent evidence that the genotype of HCV may influence the clinical course of hepatitis C² and the response to interferon therapy for this disease³ suggests that methods to identify the genotype may become clinically useful. Methods based on the polymerase chain reaction, however, are expensive, time-consuming, and limited to highly specialized laboratories.

Serotype-specific immunodominant epitopes have recently been mapped to the NS4 region of . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Lerat, H., Rumin, S., Habersetzer, F., Berby, F., Trabaud, M.-A., Trepo, C., Inchauspe, G. (1998). In Vivo Tropism of Hepatitis C Virus Genomic Sequences in Hematopoietic Cells: Influence of Viral Load, Viral Genotype, and Cell Phenotype. Blood 91: 3841-3849 [Abstract] [Full Text]  
• Di Marco, V., Iacono, O. L., Almasio, P., Ciaccio, C., Capra, M., Rizzo, M., Malizia, R., Maggio, A., Fabiano, C., Barbaria, F., Craxi, A. (1997). Long-Term Efficacy of alpha -Interferon in beta -Thalassemics With Chronic Hepatitis C. Blood 90: 2207-2212 [Abstract] [Full Text]