The vessel wall is an active, integrated organ composed of endothelial,smooth-muscle, and fibroblast cells coupled to each other ina complex autocrine-paracrine set of interactions. The vasculatureis capable of sensing changes within its milieu, integratingthese signals by intercellular communication, and changing itselfthrough the local production of mediators that influence structureas well as function. Vascular remodeling is an active processof structural alteration that involves changes in at least fourcellular processes -- cell growth, cell death, cell migration,and production or degradation of extracellular matrix -- andis dependent on a dynamic interaction between locally . . . [Full Text of this Article]
Endothelium as a Sensor and Transducer of Signals
Hemodynamic Stimuli
Endothelium-Specific Receptor-Coupled Events
Endothelium and Mediator-Effector Molecules Involved with Remodeling
Role of Matrix Modulators in Vascular Remodeling
The Clinical Implications of Vascular Remodeling
Vein Bypass Grafts
Ductus Arteriosus
Pulmonary Hypertension
Systemic Hypertension
Atherosclerosis
Restenosis after Angioplasty
Conclusions
Source Information
From the Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Dr., Stanford, CA 94305-5246, where reprint requests should be addressed to Dr. Dzau.
References
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