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Previous Volume 330:1565-1570 June 2, 1994 Number 22 Next

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ABSTRACT

Background After the occlusion of an internal carotid artery the principal source of collateral flow is through the arteries of the circle of Willis, but the size and patency of these arteries are quite variable. Study of the anatomy of the collateral pathways in patients with internal-carotid-artery occlusion with or without infarction in the watershed area of the deep white matter may identify patterns that afford protection from ischemic infarction.

Methods Using conventional magnetic resonance imaging and three-dimensional phase-contrast magnetic resonance angiography, we evaluated 29 consecutive patients (32 hemispheres at risk) with angiographically proved occlusion of the internal carotid artery. Four collateral pathways to the occluded vessel were evaluated: the proximal segment of the anterior cerebral artery, the posterior communicating artery, the ophthalmic artery, and leptomeningeal collateral vessels from the posterior cerebral artery.

Results Only features of the ipsilateral posterior communicating artery were related to the risk of watershed infarction. The presence of posterior communicating arteries measuring at least 1 mm in diameter was associated with the absence of watershed infarction (13 hemispheres, no infarcts; P<0.001). Conversely, there were 4 watershed infarcts in the 6 hemispheres with posterior communicating arteries measuring less than 1 mm in diameter and 10 infarcts in the 13 hemispheres with no detectable flow in the ipsilateral posterior communicating artery.

Conclusions A small (<1 mm in diameter) or absent ipsilateral posterior communicating artery is a risk factor for ischemic cerebral infarction in patients with internal-carotid-artery occlusion.

Source Information

From the Departments of Radiology (D.F.S., M.P.M., M.R.R., N.J.P., D.R.E.) and Neurosurgery (G.K.S.), Stanford University Medical Center, and the Department of Statistics, Stanford University (I.M.J., D.B.B.), Stanford, Calif.

Address reprint requests to Dr. Enzmann at the Department of Radiology, S072 Stanford University Medical Center, Stanford, CA 94305-5105.

Full Text of this Article

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Posterior Communicating Artery and Ischemic Stroke
Brown W. D., Gilles F. H., Nelson M. D., Bowen J.R.C., Schomer D. F., Enzmann D.R.
Extract | Full Text  
N Engl J Med 1994; 331:1020-1021, Oct 13, 1994. Correspondence

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