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Previous Volume 330:1580-1588 June 2, 1994 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Polarized epithelial cells transport ions, water, and macromolecules from one biologic compartment to another. These processes include absorption by enterocytes and renal tubular cells; secretion by hepatocytes, endocrine cells, and exocrine cells; and exchange by alveolar and capillary endothelial cells^1,2. The performance of these functions depends on a surface membrane organized into structurally, biochemically, and physiologically distinct apical and basolateral domains containing different ion channels, transport proteins, enzymes, and lipids.

The establishment and maintenance of these specialized surface-membrane domains is a multistage process. Alterations at any stage of this process could lead to cell dysfunction and ultimately a pathologic . . . [Full Text of this Article]

Characteristics of Polarized Epithelial Cells

Distinct Surface-Membrane Domains

Junctional Complex

Attachment between Cells and between Cells and Substratum

Actin Cytoskeleton

Establishment and Maintenance of the Polarized Phenotype

Pathologic States Related to Altered Surface-Membrane Polarity

Oncogenesis

Ischemic Injury in Proximal Renal Tubule Cells

Microvillus Inclusion Disease

Other Disorders

Summary

Source Information

From the Department of Medicine, University of Colorado School of Medicine, Denver (E.M.F., B.A.M.); the Department of Medicine, Indiana University Medical School, Indianapolis (B.A.M.); the Veterans Affairs Medical Center, Denver (E.M.F.); and the Veterans Affairs Medical Center, Indianapolis (B.A.M.).

Address reprint requests to Dr. Molitoris at Fesler Hall, Rm. 108, 1120 South Dr., Indianapolis, IN 46202-5116.

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