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Volume 330:1616-1617 June 2, 1994 Number 22
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Lack of Immunity to Bovine Serum Albumin in Insulin-Dependent Diabetes Mellitus

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by Atkinson, M. A.
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To the Editor: Atkinson and colleagues (Dec. 16 issue)1 report a lack of B-cell and T-cell immunity to bovine serum albumin (BSA) in children with insulin-dependent diabetes mellitus (IDDM). Their results are in contrast with several epidemiologic, ecologic, time-series, and experimental studies2,3.

Exposure during the first months of life to infant formulas based on cow's milk carries a significantly elevated risk of IDDM (mean odds ratio in case-control studies, 1.6; 95 percent confidence interval, 1.2 to 2.2)3. We reported elevated levels of IgG anti-BSA antibody in Finnish children with diabetes of recent onset,4 an observation confirmed in a . . . [Full Text of this Article]

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