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Transfusion medicine has undergone many changes over the century since its inception in the laboratory of Karl Landsteiner, and so have textbooks on the subject. Discoveries of numerous red-cell antigens and associated antibodies made blood-group serology the core of many of the earliest reference books. In recent years, a sharper clinical focus has emerged; information about the proper preparation and judicious use of blood components has become critical to medical practice and thus to textbooks. Now the results of research into the biochemistry and genetics of blood groups, and laboratory clues to the effects of blood transfusions on the immune
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