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Volume 330:1629-1633 June 9, 1994 Number 23 Next

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ABSTRACT

Background The renin-angiotensin system is a powerful pressor system with a major influence on salt and water homeostasis. Angiotensinogen (also called renin substrate) is a key component of this system; it is cleaved by renin to yield angiotensin I, which is then cleaved by angiotensin-converting enzyme to yield angiotensin II. The observation that plasma angiotensinogen levels correlate with blood pressure and track through families suggests that angiotensinogen may have a role in essential hypertension. We therefore investigated whether there is linkage between the angiotensinogen gene on chromosome 1q42-43 and essential hypertension.

Methods Samples of DNA from 63 white European families in which two or more members had essential hypertension were tested for linkage of the angiotensinogen gene to this disorder. Affected cousins, nephews, nieces, and half-siblings were included when possible. To test for linkage, we used as a marker a dinucleotide-repeat sequence flanking this gene, and we employed the affected-pedigree-member method of linkage analysis. Two molecular variants of the angiotensinogen gene, one encoding threonine instead of methionine at position 235 (M235T) and the other encoding methionine rather than threonine at position 174 (T174M), were also tested for possible association with essential hypertension.

Results We found significant linkage (t = 5.00, P<0.001) and association (chi-square = 53.3, P<0.001) of the angiotensinogen-gene locus to essential hypertension in the 63 multiplex families. This linkage was consistently maintained in the subgroup of subjects with diastolic pressure above 100 mm Hg and in the subgroups classified according to sex. It has been proposed previously that T174M and M235T are associated with essential hypertension. However, we found no association in our population between either polymorphism and this disorder.

Conclusions This study provides strong and consistent support for the linkage to essential hypertension of regions within or close to the angiotensinogen gene. Precisely how mutations in this region may result in hypertension remains to be determined.

Source Information

From the Departments of Clinical Pharmacology (M.C., P.M., M.L., P.T.) and Chemical Endocrinology (P.L., A.J.L.C.), St. Bartholomew's Hospital; and the Medical Research Council Molecular Medicine Group, Royal Postgraduate Medical School (M.F.) -- both in London.

Address reprint requests to Dr. Caulfield at the Department of Clinical Pharmacology, St. Bartholomew's Hospital, London EC1A 7BE, United Kingdom.

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• Ishigami, T., Tamura, K., Fujita, T., Kobayashi, I., Hibi, K., Kihara, M., Toya, Y., Ochiai, H., Umemura, S. (1999). Angiotensinogen Gene Polymorphism Near Transcription Start Site and Blood Pressure : Role of a T-to-C Transition at Intron I. Hypertension 34: 430-434 [Abstract] [Full Text]  
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• Kainulainen, K., Perola, M., Terwilliger, J., Kaprio, J., Koskenvuo, M., Syvanen, A.-C., Vartiainen, E., Peltonen, L., Kontula, K. (1999). Evidence for Involvement of the Type 1 Angiotensin II Receptor Locus in Essential Hypertension. Hypertension 33: 844-849 [Abstract] [Full Text]  
• Niu, T., Yang, J., Wang, B., Chen, W., Wang, Z., Laird, N., Wei, E., Fang, Z., Lindpaintner, K., Rogus, J. J., Xu, X. (1999). Angiotensinogen Gene Polymorphisms M235T/T174M : No Excess Transmission to Hypertensive Chinese. Hypertension 33: 698-702 [Abstract] [Full Text]  
• St. Lezin, E., Zhang, L., Yang, Y., Wang, J.-M., Wang, N., Qi, N., Steadman, J. S., Liu, W., Kren, V., Zidek, V., Krenova, D., Churchill, P. C., Churchill, M. C., Pravenec, M. (1999). Effect of Chromosome 19 Transfer on Blood Pressure in the Spontaneously Hypertensive Rat. Hypertension 33: 256-260 [Abstract] [Full Text]  
• Pratt, J. H., Ambrosius, W. T., Tewksbury, D. A., Wagner, M. A., Zhou, L., Hanna, M. P. (1998). Serum Angiotensinogen Concentration in Relation to Gonadal Hormones, Body Size, and Genotype in Growing Young People. Hypertension 32: 875-879 [Abstract] [Full Text]  
• Hunt, S. C., Cook, N. R., Oberman, A., Cutler, J. A., Hennekens, C. H., Allender, P. S., Walker, W. G., Whelton, P. K., Williams, R. R. (1998). Angiotensinogen Genotype, Sodium Reduction, Weight Loss, and Prevention of Hypertension : Trials of Hypertension Prevention, Phase II. Hypertension 32: 393-401 [Abstract] [Full Text]  
• Tamura, K., Umemura, S., Nyui, N., Hibi, K., Ishigami, T., Kihara, M., Toya, Y., Ishii, M. (1998). Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch. Am. J. Physiol. Regul. Integr. Comp. Physiol. 275: R1-R9 [Abstract] [Full Text]  
• Mazzolai, L., Nussberger, J., Aubert, J.-F., Brunner, D. B., Gabbiani, G., Brunner, H. R., Pedrazzini, T. (1998). Blood Pressure–Independent Cardiac Hypertrophy Induced by Locally Activated Renin-Angiotensin System. Hypertension 31: 1324-1330 [Abstract] [Full Text]  
• Makino, N., Sugano, M., Ohtsuka, S., Sawada, S. (1998). Intravenous Injection With Antisense Oligodeoxynucleotides Against Angiotensinogen Decreases Blood Pressure in Spontaneously Hypertensive Rats. Hypertension 31: 1166-1170 [Abstract] [Full Text]  
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• Kato, N., Sugiyama, T., Nabika, T., Morita, H., Kurihara, H., Yazaki, Y., Yamori, Y. (1998). Lack of Association Between the {alpha}-Adducin Locus and Essential Hypertension in the Japanese Population. Hypertension 31: 730-733 [Abstract] [Full Text]  
• Yang, G., Sigmund, C. D. (1998). Regulatory Elements Required for Human Angiotensinogen Expression in HepG2 Cells Are Dispensable in Transgenic Mice. Hypertension 31: 734-740 [Abstract] [Full Text]  
• Rogus, J. J., Moczulski, D., Freire, M. B. S., Yang, Y., Warram, J. H., Krolewski, A. S. (1998). Diabetic Nephropathy Is Associated With AGT Polymorphism T235 : Results of a Family-Based Study. Hypertension 31: 627-631 [Abstract] [Full Text]  
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• Kunz, R., Kreutz, R., Beige, J., Distler, A., Sharma, A. M. (1997). Association Between the Angiotensinogen 235T-Variant and Essential Hypertension in Whites : A Systematic Review and Methodological Appraisal. Hypertension 30: 1331-1337 [Abstract] [Full Text]  
• Yanai, K., Saito, T., Hirota, K., Kobayashi, H., Murakami, K., Fukamizu, A. (1997). Molecular Variation of the Human Angiotensinogen Core Promoter Element Located between the TATA Box and Transcription Initiation Site Affects Its Transcriptional Activity. J. Biol. Chem. 272: 30558-30562 [Abstract] [Full Text]  
• Corvol, P., Jeunemaitre, X. (1997). Molecular Genetics of Human Hypertension: Role of Angiotensinogen. Endocr. Rev. 18: 662-677 [Abstract] [Full Text]  
• Kotanko, P., Binder, A., Tasker, J., DeFreitas, P., Kamdar, S., Clark, A. J. L., Skrabal, F., Caulfield, M. (1997). Essential Hypertension in African Caribbeans Associates With a Variant of the ß2-Adrenoceptor. Hypertension 30: 773-776 [Abstract] [Full Text]  
• Sato, N., Katsuya, T., Rakugi, H., Takami, S., Nakata, Y., Miki, T., Higaki, J., Ogihara, T. (1997). Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese. Hypertension 30: 321-325 [Abstract] [Full Text]  
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• Bloem, L. J., Foroud, T. M., Ambrosius, W. T., Hanna, M. P., Tewksbury, D. A., Pratt, J. H. (1997). Association of the Angiotensinogen Gene to Serum Angiotensinogen in Blacks and Whites. Hypertension 29: 1078-1082 [Abstract] [Full Text]  
• Schunkert, H., Hense, H.-W., Gimenez-Roqueplo, A., Stieber, J., Keil, U., Riegger, G. A.J., Jeunemaitre, X. (1997). The Angiotensinogen T235 Variant and the Use of Antihypertensive Drugs in a Population-Based Cohort. Hypertension 29: 628-633 [Abstract] [Full Text]  
• Kiema, T.-R., Kauma, H., Rantala, A. O., Lilja, M., Reunanen, A., Kesaniemi, Y. A., Savolainen, M. J. (1996). Variation at the Angiotensin-Converting Enzyme Gene and Angiotensinogen Gene Loci in Relation to Blood Pressure. Hypertension 28: 1070-1075 [Abstract] [Full Text]  
• Caulfield, M., Lavender, P., Newell-Price, J., Kamdar, S., Farrall, M., Clark, A. J.L. (1996). Angiotensinogen in Human Essential Hypertension. Hypertension 28: 1123-1125 [Abstract] [Full Text]  
• Hingorani, A. D., Sharma, P., Jia, H., Hopper, R., Brown, M. J. (1996). Blood Pressure and the M235T Polymorphism of the Angiotensinogen Gene. Hypertension 28: 907-911 [Abstract] [Full Text]  
• McLaughlin, K. J., Harden, P. N., Ueda, S., Boulton-Jones, J. M., Connell, J. M.C., Jardine, A. G. (1996). The Role of Genetic Polymorphisms of Angiotensin-Converting Enzyme in the Progression of Renal Diseases. Hypertension 28: 912-915 [Abstract] [Full Text]  
• Yanai, K., Nibu, Y., Murakami, K., Fukamizu, A. (1996). A cis-Acting DNA Element Located between TATA Box and Transcription Initiation Site Is Critical in Response to Regulatory Sequences in Human Angiotensinogen Gene. J. Biol. Chem. 271: 15981-15986 [Abstract] [Full Text]  
• Badenhop, R. F., Wang, X. L., Wilcken, D. E.L. (1996). Association Between an Angiotensinogen Microsatellite Marker in Children and Coronary Events in Their Grandparents. Circulation 93: 2092-2096 [Abstract] [Full Text]  
• Doria, A., Onuma, T., Gearin, G., Freire, M. B. S., Warram, J. H., Krolewski, A. S. (1996). Angiotensinogen Polymorphism M235T, Hypertension, and Nephropathy in Insulin-Dependent Diabetes. Hypertension 27: 1134-1139 [Abstract] [Full Text]  
• Gimenez-Roqueplo, A.-P., Leconte, I., Cohen, P., Simon, D., Guyene, T. T., Célerier, Jérôm., Pau, B., Corvol, P., Clauser, E., Jeunemaitre, X. (1996). The Natural Mutation Y248C of Human Angiotensinogen Leads to Abnormal Glycosylation and Altered Immunological Recognition of the Protein. J. Biol. Chem. 271: 9838-9844 [Abstract] [Full Text]  
• Brasier, A. R., Li, J., Wimbish, K. A. (1996). Tumor Necrosis Factor Activates Angiotensinogen Gene Expression by the Rel A Transactivator. Hypertension 27: 1009-1017 [Abstract] [Full Text]  
• Brasier, A. R., Li, J. (1996). Mechanisms for Inducible Control of Angiotensinogen Gene Transcription. Hypertension 27: 465-475 [Abstract] [Full Text]  
• Morishita, R., Higaki, J., Tomita, N., Aoki, M., Moriguchi, A., Tamura, K., Murakami, K., Kaneda, Y., Ogihara, T. (1996). Role of Transcriptional cis-Elements, Angiotensinogen Gene–Activating Elements, of Angiotensinogen Gene in Blood Pressure Regulation. Hypertension 27: 502-507 [Abstract] [Full Text]  
• Rotimi, C., Puras, A., Cooper, R., McFarlane-Anderson, N., Forrester, T., Ogunbiyi, O., Morrison Ryk Ward, L. (1996). Polymorphisms of Renin-Angiotensin Genes Among Nigerians, Jamaicans, and African Americans. Hypertension 27: 558-563 [Abstract] [Full Text]  
• Bromberg, J.E.C., Rinkel, G.J.E., Algra, A., van den Berg, U.A.C., Tjin-A-Ton, M.L.R., van Gijn, J. (1996). Hypertension, Stroke, and Coronary Heart Disease in Relatives of Patients With Subarachnoid Hemorrhage. Stroke 27: 7-9 [Abstract] [Full Text]  
• Postma, D. S., Bleecker, E. R., Amelung, P. J., Holroyd, K. J., Xu, J., Panhuysen, C. I.M., Meyers, D. A., Levitt, R. C. (1995). Genetic Susceptibility to Asthma -- Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy. NEJM 333: 894-900 [Abstract] [Full Text]  
• Teo, K. K (1995). Angiotensin converting enzyme genotypes and disease. BMJ 311: 763-764 [Full Text]  
• Hubner, N., Kreutz, R., Takahashi, S., Ganten, D., Lindpaintner, K. (1995). Altered Angiotensinogen Amino Acid Sequence and Plasma Angiotensin II Levels in Genetically Hypertensive Rats : A Study on Cause and Effect. Hypertension 26: 279-284 [Abstract] [Full Text]  
• Tomita, N., Morishita, R., Higaki, J., Aoki, M., Nakamura, Y., Mikami, H., Fukamizu, A., Murakami, K., Kaneda, Y., Ogihara, T. (1995). Transient Decrease in High Blood Pressure by In Vivo Transfer of Antisense Oligodeoxynucleotides Against Rat Angiotensinogen. Hypertension 26: 131-136 [Abstract] [Full Text]  
• Lodwick, D., Kaiser, M. A., Harris, J., Cumin, F., Vincent, M., Samani, N. J. (1995). Analysis of the Role of Angiotensinogen in Spontaneous Hypertension. Hypertension 25: 1245-1251 [Abstract] [Full Text]  
• Kamitani, A., Rakugi, H., Higaki, J., Ohishi, M., Shi, S.-J., Takami, S., Nakata, Y., Higashino, Y., Fujii, K., Mikami, H., Miki, T., Ogihara, T. (1995). Enhanced Predictability of Myocardial Infarction in Japanese by Combined Genotype Analysis. Hypertension 25: 950-953 [Abstract] [Full Text]  
• Iwai, N., Shimoike, H., Ohmichi, N., Kinoshita, M. (1995). Angiotensinogen Gene and Blood Pressure in the Japanese Population. Hypertension 25: 688-693 [Abstract] [Full Text]  
• Haber, E. (1995). Angiotensin-Converting Enzyme and Lipoprotein(a) as Risk Factors for Myocardial Infarction. Circulation 91: 1888-1890 [Full Text]