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Correspondence
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Volume 330:1758-1759 June 16, 1994 Number 24
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More on Zidovudine in Asymptomatic HIV Infection

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 by Cooper, D. A.
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To the Editor: The report of the randomized trial by the European-Australian Collaborative Group of zidovudine in asymptomatic HIV infection (July 29 issue)1 contains a serious statistical error. Berger has already pointed out (Dec. 16 issue)2 that changes in CD4+ cell counts are of questionable clinical importance and should not have been combined with AIDS and AIDS-related complex in the analysis of disease progression. Far more serious, however, was the failure to analyze the results according to random assignment with complete follow-up. Patients' data were censored three months after treatment stopped, leading to 173 withdrawals in the zidovudine group and . . . [Full Text of this Article]

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