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A 58-year-old woman was admitted to the hospital because of intractable diarrhea after chemotherapy for carcinoma of the tongue.
Five months before admission, the patient had received radiation therapy for a stage T4N2cM0 squamous-cell carcinoma of the tongue, followed by the administration of two cycles of fluorouracil, cisplatin, bleomycin, and methotrexate; the second cycle was begun 22 days before admission. The patient experienced only minor soreness of the mouth after the first cycle of chemotherapy and negligible side effects during the two weeks after the second cycle.
Four days before admission, diarrhea developed, with crampy abdominal pain, nausea, dry heaves,
Differential Diagnosis
Clinical Diagnosis
Dr. Sherwood L. Gorbach's Diagnosis
Pathological Discussion
Anatomical Diagnosis
Addendum
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